Herbicide exposure modifies GSTP1 haplotype association to parkinson onset age : The GenePD study
Identifieur interne : 002926 ( Main/Exploration ); précédent : 002925; suivant : 002927Herbicide exposure modifies GSTP1 haplotype association to parkinson onset age : The GenePD study
Auteurs : J. B. Wilk [États-Unis] ; J. E. Tobin [États-Unis] ; O. Suchowersky [Canada] ; H. A. Shill [États-Unis] ; C. Klein [Allemagne] ; G. F. Wooten [États-Unis] ; M. F. Lew [États-Unis] ; M. H. Mark [États-Unis] ; M. Guttman [Canada] ; R. L. Watts [États-Unis] ; C. Singer [États-Unis] ; J. H. Growdon [États-Unis] ; J. C. Latourelle [États-Unis] ; M. H. Saint-Hilaire [États-Unis] ; A. L. Destefano [États-Unis] ; R. Prakash [États-Unis] ; S. Williamson [États-Unis] ; C. J. Berg [États-Unis] ; M. Sun [États-Unis] ; S. Goldwurm [Italie] ; G. Pezzoli [Italie] ; B. A. Racette [États-Unis] ; J. S. Perlmutter [États-Unis] ; A. Parsian [États-Unis] ; K. B. Baker [États-Unis] ; M. L. Giroux [États-Unis] ; I. Litvan [États-Unis] ; P. P. Pramstaller [Italie] ; G. Nicholson [Australie] ; D. J. Burn [Royaume-Uni] ; P. F. Chinnery [Royaume-Uni] ; P. Vieregge [Allemagne] ; J. T. Slevin [États-Unis] ; F. Cambi [États-Unis] ; M. E. Macdonald [États-Unis] ; J. F. Gusella [États-Unis] ; R. H. Myers [États-Unis] ; L. I. Golbe [États-Unis]Source :
- Neurology [ 0028-3878 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Herbicide.
English descriptors
- KwdEn :
Abstract
Background: Polymorphisms in the glutathione S-transferase pi gene (GSTP1), encoding GSTP1-1, a detoxification enzyme, may increase the risk of Parkinson disease (PD) with exposure to pesticides. Using the GenePD Study sample of familial PD cases, we explored whether GSTP1 polymorphisms were associated with the age at onset of PD symptoms and whether that relation was modified by exposure to herbicides. Methods: Seven single-nucleotide polymorphisms (SNPs) were genotyped and tested for association with PD onset age in men in three strata: no exposure to herbicides, residential exposure to herbicides, and occupational exposure to herbicides. Haplotypes were similarly evaluated in stratified analyses. Results: Three SNPs were associated with PD onset age in the group of men occupationally exposed to herbicides. Three additional SNPs had significant trends for the association of PD onset age across the herbicide exposure groups. Haplotype results also provided evidence that the relation between GSTP1 and onset age is modified by herbicide exposure. One haplotype was associated with an approximately 8-years-earlier onset in the occupationally exposed group and a 2.8-years-later onset in the nonexposed group. Conclusions: Herbicide exposure may be an effect modifier of the relation between glutathione S-transferase pi gene polymorphisms and onset age in familial PD.
Affiliations:
- Allemagne, Australie, Canada, Italie, Royaume-Uni, États-Unis
- Alberta, Californie, Missouri (État), Ontario
- Calgary, Los Angeles, Saint-Louis (Missouri), Sydney, Toronto
- Université Washington de Saint-Louis, Université de Calgary, Université de Californie du Sud, Université de Toronto, École de médecine (Université Washington de Saint-Louis)
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Williamson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Berg, C J" sort="Berg, C J" uniqKey="Berg C" first="C. J." last="Berg">C. J. Berg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Sun, M" sort="Sun, M" uniqKey="Sun M" first="M." last="Sun">M. Sun</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>19 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1><s2>Milano</s2><s3>ITA</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G." last="Pezzoli">G. Pezzoli</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1><s2>Milano</s2><s3>ITA</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Racette, B A" sort="Racette, B A" uniqKey="Racette B" first="B. A." last="Racette">B. A. Racette</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>Saint Louis, MO</s2><s3>USA</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>Saint Louis, MO</s2><s3>USA</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Parsian, A" sort="Parsian, A" uniqKey="Parsian A" first="A." last="Parsian">A. Parsian</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences</s1><s2>AR</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>AR</wicri:noRegion></affiliation></author><author><name sortKey="Baker, K B" sort="Baker, K B" uniqKey="Baker K" first="K. B." last="Baker">K. B. Baker</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cleveland, OH</wicri:noRegion></affiliation></author><author><name sortKey="Giroux, M L" sort="Giroux, M L" uniqKey="Giroux M" first="M. L." last="Giroux">M. L. Giroux</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cleveland, OH</wicri:noRegion></affiliation></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Neurology, University of Louisville School of Medicine</s1><s2>Louisville, KY</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Louisville, KY</wicri:noRegion></affiliation></author><author><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Department of Neurology, General Regional Hospital Bolzano</s1><s2>Bolzano</s2><s3>ITA</s3><sZ>28 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Nicholson, G" sort="Nicholson, G" uniqKey="Nicholson G" first="G." last="Nicholson">G. Nicholson</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital</s1><s2>Sydney</s2><s3>AUS</s3><sZ>29 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Regional Neurosciences Centre, Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Chinnery, P F" sort="Chinnery, P F" uniqKey="Chinnery P" first="P. F." last="Chinnery">P. F. Chinnery</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Regional Neurosciences Centre, Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Klinik fur Neurologie, Klinikum Lippe-Lemgo</s1><s2>Lemgo</s2><s3>DEU</s3><sZ>32 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lemgo</wicri:noRegion><wicri:noRegion>Klinikum Lippe-Lemgo</wicri:noRegion><wicri:noRegion>Lemgo</wicri:noRegion></affiliation></author><author><name sortKey="Slevin, J T" sort="Slevin, J T" uniqKey="Slevin J" first="J. T." last="Slevin">J. T. Slevin</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Department of Neurology, University of Kentucky College of Medicine</s1><s3>USA</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, University of Kentucky College of Medicine</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Veterans Affairs Medical Center</s1><s2>Lexington, KY</s2><s3>USA</s3><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Veterans Affairs Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Cambi, F" sort="Cambi, F" uniqKey="Cambi F" first="F." last="Cambi">F. Cambi</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Department of Neurology, University of Kentucky College of Medicine</s1><s3>USA</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, University of Kentucky College of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Macdonald, M E" sort="Macdonald, M E" uniqKey="Macdonald M" first="M. E." last="Macdonald">M. E. Macdonald</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>19 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Gusella, J F" sort="Gusella, J F" uniqKey="Gusella J" first="J. F." last="Gusella">J. F. Gusella</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>19 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1><s2>New Brunswick, NJ</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick, NJ</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0076731</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 07-0076731 INIST</idno><idno type="RBID">Pascal:07-0076731</idno><idno type="wicri:Area/PascalFrancis/Corpus">000777</idno><idno type="wicri:Area/PascalFrancis/Curation">000543</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000726</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000726</idno><idno type="wicri:doubleKey">0028-3878:2006:Wilk J:herbicide:exposure:modifies</idno><idno type="wicri:Area/Main/Merge">002C24</idno><idno type="wicri:Area/Main/Curation">002926</idno><idno type="wicri:Area/Main/Exploration">002926</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Herbicide exposure modifies GSTP1 haplotype association to parkinson onset age : The GenePD study</title><author><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Tobin, J E" sort="Tobin, J E" uniqKey="Tobin J" first="J. E." last="Tobin">J. E. Tobin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Anatomy and Neurobiology, Boston University School of Medicine</s1><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Anatomy and Neurobiology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Shill, H A" sort="Shill, H A" uniqKey="Shill H" first="H. A." last="Shill">H. A. Shill</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Muhammad Ali Parkinson Center, Barrow Neurological Institute</s1><s2>Phoenix, AZ</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Phoenix, AZ</wicri:noRegion></affiliation></author><author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, University of Virginia Health System</s1><s2>Charlottesville, VA</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville, VA</wicri:noRegion></affiliation></author><author><name sortKey="Lew, M F" sort="Lew, M F" uniqKey="Lew M" first="M. F." last="Lew">M. F. Lew</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Neurology, University of Southern California</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1><s2>New Brunswick, NJ</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick, NJ</wicri:noRegion></affiliation></author><author><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Medicine, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Watts, R L" sort="Watts, R L" uniqKey="Watts R" first="R. L." last="Watts">R. L. Watts</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Neurology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Birmingham, AL</wicri:noRegion></affiliation></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, University of Miami</s1><s2>Miami, FL</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Miami, FL</wicri:noRegion></affiliation></author><author><name sortKey="Growdon, J H" sort="Growdon, J H" uniqKey="Growdon J" first="J. H." last="Growdon">J. H. Growdon</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Latourelle, J C" sort="Latourelle, J C" uniqKey="Latourelle J" first="J. C." last="Latourelle">J. C. Latourelle</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Saint Hilaire, M H" sort="Saint Hilaire, M H" uniqKey="Saint Hilaire M" first="M. H." last="Saint-Hilaire">M. H. Saint-Hilaire</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A. L." last="Destefano">A. L. Destefano</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Prakash, R" sort="Prakash, R" uniqKey="Prakash R" first="R." last="Prakash">R. Prakash</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Williamson, S" sort="Williamson, S" uniqKey="Williamson S" first="S." last="Williamson">S. Williamson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Berg, C J" sort="Berg, C J" uniqKey="Berg C" first="C. J." last="Berg">C. J. Berg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Sun, M" sort="Sun, M" uniqKey="Sun M" first="M." last="Sun">M. Sun</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>19 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1><s2>Milano</s2><s3>ITA</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G." last="Pezzoli">G. Pezzoli</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1><s2>Milano</s2><s3>ITA</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Racette, B A" sort="Racette, B A" uniqKey="Racette B" first="B. A." last="Racette">B. A. Racette</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>Saint Louis, MO</s2><s3>USA</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>Saint Louis, MO</s2><s3>USA</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Parsian, A" sort="Parsian, A" uniqKey="Parsian A" first="A." last="Parsian">A. Parsian</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences</s1><s2>AR</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>AR</wicri:noRegion></affiliation></author><author><name sortKey="Baker, K B" sort="Baker, K B" uniqKey="Baker K" first="K. B." last="Baker">K. B. Baker</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cleveland, OH</wicri:noRegion></affiliation></author><author><name sortKey="Giroux, M L" sort="Giroux, M L" uniqKey="Giroux M" first="M. L." last="Giroux">M. L. Giroux</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cleveland, OH</wicri:noRegion></affiliation></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Neurology, University of Louisville School of Medicine</s1><s2>Louisville, KY</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Louisville, KY</wicri:noRegion></affiliation></author><author><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Department of Neurology, General Regional Hospital Bolzano</s1><s2>Bolzano</s2><s3>ITA</s3><sZ>28 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Nicholson, G" sort="Nicholson, G" uniqKey="Nicholson G" first="G." last="Nicholson">G. Nicholson</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital</s1><s2>Sydney</s2><s3>AUS</s3><sZ>29 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Regional Neurosciences Centre, Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Chinnery, P F" sort="Chinnery, P F" uniqKey="Chinnery P" first="P. F." last="Chinnery">P. F. Chinnery</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Regional Neurosciences Centre, Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Klinik fur Neurologie, Klinikum Lippe-Lemgo</s1><s2>Lemgo</s2><s3>DEU</s3><sZ>32 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lemgo</wicri:noRegion><wicri:noRegion>Klinikum Lippe-Lemgo</wicri:noRegion><wicri:noRegion>Lemgo</wicri:noRegion></affiliation></author><author><name sortKey="Slevin, J T" sort="Slevin, J T" uniqKey="Slevin J" first="J. T." last="Slevin">J. T. Slevin</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Department of Neurology, University of Kentucky College of Medicine</s1><s3>USA</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, University of Kentucky College of Medicine</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Veterans Affairs Medical Center</s1><s2>Lexington, KY</s2><s3>USA</s3><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Veterans Affairs Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Cambi, F" sort="Cambi, F" uniqKey="Cambi F" first="F." last="Cambi">F. Cambi</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Department of Neurology, University of Kentucky College of Medicine</s1><s3>USA</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, University of Kentucky College of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Macdonald, M E" sort="Macdonald, M E" uniqKey="Macdonald M" first="M. E." last="Macdonald">M. E. Macdonald</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>19 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Gusella, J F" sort="Gusella, J F" uniqKey="Gusella J" first="J. F." last="Gusella">J. F. Gusella</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>19 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1><s2>New Brunswick, NJ</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick, NJ</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Haplotype</term><term>Herbicide</term><term>Nervous system diseases</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Herbicide</term><term>Haplotype</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Herbicide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Polymorphisms in the glutathione S-transferase pi gene (GSTP1), encoding GSTP1-1, a detoxification enzyme, may increase the risk of Parkinson disease (PD) with exposure to pesticides. Using the GenePD Study sample of familial PD cases, we explored whether GSTP1 polymorphisms were associated with the age at onset of PD symptoms and whether that relation was modified by exposure to herbicides. Methods: Seven single-nucleotide polymorphisms (SNPs) were genotyped and tested for association with PD onset age in men in three strata: no exposure to herbicides, residential exposure to herbicides, and occupational exposure to herbicides. Haplotypes were similarly evaluated in stratified analyses. Results: Three SNPs were associated with PD onset age in the group of men occupationally exposed to herbicides. Three additional SNPs had significant trends for the association of PD onset age across the herbicide exposure groups. Haplotype results also provided evidence that the relation between GSTP1 and onset age is modified by herbicide exposure. One haplotype was associated with an approximately 8-years-earlier onset in the occupationally exposed group and a 2.8-years-later onset in the nonexposed group. Conclusions: Herbicide exposure may be an effect modifier of the relation between glutathione S-transferase pi gene polymorphisms and onset age in familial PD.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Alberta</li><li>Californie</li><li>Missouri (État)</li><li>Ontario</li></region><settlement><li>Calgary</li><li>Los Angeles</li><li>Saint-Louis (Missouri)</li><li>Sydney</li><li>Toronto</li></settlement><orgName><li>Université Washington de Saint-Louis</li><li>Université de Calgary</li><li>Université de Californie du Sud</li><li>Université de Toronto</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name></noRegion><name sortKey="Baker, K B" sort="Baker, K B" uniqKey="Baker K" first="K. B." last="Baker">K. B. Baker</name><name sortKey="Berg, C J" sort="Berg, C J" uniqKey="Berg C" first="C. J." last="Berg">C. J. Berg</name><name sortKey="Cambi, F" sort="Cambi, F" uniqKey="Cambi F" first="F." last="Cambi">F. Cambi</name><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A. L." last="Destefano">A. L. Destefano</name><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A. L." last="Destefano">A. L. Destefano</name><name sortKey="Giroux, M L" sort="Giroux, M L" uniqKey="Giroux M" first="M. L." last="Giroux">M. L. Giroux</name><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name><name sortKey="Growdon, J H" sort="Growdon, J H" uniqKey="Growdon J" first="J. H." last="Growdon">J. H. Growdon</name><name sortKey="Gusella, J F" sort="Gusella, J F" uniqKey="Gusella J" first="J. F." last="Gusella">J. F. Gusella</name><name sortKey="Latourelle, J C" sort="Latourelle, J C" uniqKey="Latourelle J" first="J. C." last="Latourelle">J. C. Latourelle</name><name sortKey="Lew, M F" sort="Lew, M F" uniqKey="Lew M" first="M. F." last="Lew">M. F. Lew</name><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><name sortKey="Macdonald, M E" sort="Macdonald, M E" uniqKey="Macdonald M" first="M. E." last="Macdonald">M. E. Macdonald</name><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name><name sortKey="Parsian, A" sort="Parsian, A" uniqKey="Parsian A" first="A." last="Parsian">A. Parsian</name><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name><name sortKey="Prakash, R" sort="Prakash, R" uniqKey="Prakash R" first="R." last="Prakash">R. Prakash</name><name sortKey="Racette, B A" sort="Racette, B A" uniqKey="Racette B" first="B. A." last="Racette">B. A. Racette</name><name sortKey="Saint Hilaire, M H" sort="Saint Hilaire, M H" uniqKey="Saint Hilaire M" first="M. H." last="Saint-Hilaire">M. H. Saint-Hilaire</name><name sortKey="Shill, H A" sort="Shill, H A" uniqKey="Shill H" first="H. A." last="Shill">H. A. Shill</name><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name><name sortKey="Slevin, J T" sort="Slevin, J T" uniqKey="Slevin J" first="J. T." last="Slevin">J. T. Slevin</name><name sortKey="Slevin, J T" sort="Slevin, J T" uniqKey="Slevin J" first="J. T." last="Slevin">J. T. Slevin</name><name sortKey="Sun, M" sort="Sun, M" uniqKey="Sun M" first="M." last="Sun">M. Sun</name><name sortKey="Tobin, J E" sort="Tobin, J E" uniqKey="Tobin J" first="J. E." last="Tobin">J. E. Tobin</name><name sortKey="Tobin, J E" sort="Tobin, J E" uniqKey="Tobin J" first="J. E." last="Tobin">J. E. Tobin</name><name sortKey="Watts, R L" sort="Watts, R L" uniqKey="Watts R" first="R. L." last="Watts">R. L. Watts</name><name sortKey="Williamson, S" sort="Williamson, S" uniqKey="Williamson S" first="S." last="Williamson">S. Williamson</name><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name></country><country name="Canada"><region name="Alberta"><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name></region><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name></country><country name="Allemagne"><noRegion><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name></noRegion><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name></country><country name="Italie"><noRegion><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name></noRegion><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G." last="Pezzoli">G. Pezzoli</name><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name></country><country name="Australie"><noRegion><name sortKey="Nicholson, G" sort="Nicholson, G" uniqKey="Nicholson G" first="G." last="Nicholson">G. Nicholson</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name></noRegion><name sortKey="Chinnery, P F" sort="Chinnery, P F" uniqKey="Chinnery P" first="P. F." last="Chinnery">P. F. Chinnery</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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